Levamin

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Product Group	:	Antiparasitics
Pharmaceutical Form	:	Powder for Oral Solution
Active Ingredient	:	Levamisole hydrochloride
Target Animal	:	Cattle, Sheep, Poultry
Package Form	:	In 500 g and 1000 g white polyethylene jars

Composition - Pharmacological Properties
Indications – Usage
Undesirable Effects – Warnings

COMPOSITION
It is a white colored powder containing 150 mg levamisole hydrochloride per gram.

PHARMACOLOGICAL PROPERTIES
Levamisole is an imidazole derivative with antihelminthic activity. Levamisole exerts its effect by paralyzing parasites. This paralysis occurs as a result of the parasites' autonomic ganglia being stimulated in a manner similar to nicotine. Levamisole has an antihelminthic effect on both adult and larval forms of gastrointestinal lungworms and ascarids that cause invasion.

After oral administration, it is rapidly absorbed from the digestive tract and distributed throughout the body. Blood concentration peaks within 1-2 hours. The plasma half-life in cattle is 4-6 hours. Approximately 40% of the administered drug is excreted primarily in feces and urine within the first 12 hours, with excretion continuing for 8 days. It is effective against most lung and gastrointestinal roundworms and ascarids.

AREA OF USE/INDICATIONS
Levamin Powder for Oral Solution is a broad-spectrum anthelmintic preparation.

It is used for the control and treatment of internal parasites given below in cattle, sheep, and poultry.

Cattle:

Gastrointestinal nematodes: Ostertagia spp., Haemonchus spp., Trichostrongylus spp., Cooperia spp., Oesophagostomum spp., Nematodirus spp., Strongyloides spp., Bunostomum spp., Trichuris spp. Toxacara spp., Neoascaris spp.

Lungworms: Dictyocaulus viviparus.

Sheep:

Gastrointestinal nematodes: Ostertagia spp., Haemonchus spp., Trichostrongylus spp., Cooperia spp., Oesophagostomum spp., Nematodirus spp., Strongyloides spp., Chabertia spp., Trichuris spp.

Lungworms: Dictyocaulus filaria, Protostrongylus rufescens

Poultry:

Heterakis galinarum, Syngamus trachea, Oxyspirura mansoni, Capilaria spp., Amidostomum spp. Ascaridia spp.

USAGE AND DOSAGE

Cattle and Sheep;

Pharmacological dose: 7,5 mg/kg body weight, orally

Poultry: 18-36 mg/kg body weight, orally

Practical dose table;

Cattle – Sheep	1 g / 20 kg body weight
Poultry	1 g / 5 kg body weight

SPECIAL CLINICAL INFORMATION AND SPECIAL WARNINGS FOR TARGET SPECIES

It is recommended to administer as a preventive against lice, especially at the beginning of spring and autumn.

After parasites are detected, immediate medication is recommended, to be repeated after 1-1.5 months.

In poultry, it is recommended to mix it into the drinking water.

Use during pregnancy, lactation and laying: It is safe to use the product during preganancy.

ADVERSE EFFECTS

There are no significant side effects when used orally. Side effects such as mild shortness of breath, hypotension, and urination are temporary and disappear within a couple of hours.

DRUG INTERACTIONS

It should not be used in combination with organophosphorus compounds, phenothiazines, tetrahydroprimidines, diethylcarbamazine, chloramphenicol, and procaine.

WITHDRAWAL PERIODS

Meat: 14 days for cattle, 21 days for sheep and 7 days for poultry.

It is not used in dairy cows and sheep from which milk is obtained for human consumption and in poultry from which eggs are obtained for human consumption.

CONTRAINDICATIONS

The use of levamisole with organophosphorus compounds is contraindicated. For this reason, organophosphorus compounds should not be used 14 days before and 14 days after the administration of Levamin Powder for Oral Solution. It should not be used in cases of liver and kidney failure.

GENERAL WARNINGS

Consult a veterinarian before use and if any unexpected effects occur. Keep out of reach of children.

PRECAUTIONS TO BE TAKEN BY THE ADMINISTRATOR AND WARNINGS FOR VETERINARY SURGEON

Gloves should be worn during use, and hands should be washed thoroughly after use.

Sensitivity reactions may be observed in a small number of people applying the drug. It should not come into contact with the skin or eyes; if contact occurs, it should be washed off with plenty of water.

Nothing should be eaten or drunk during use, and smoking should be avoided.

STORAGE CONDITIONS AND SHELF LIFE

It should be stored in the original packages, below 25°C, away from sunlight, without refrigeration or freezing. The shelf life is 3 years.

DISPOSAL AFTER USE AND WARNINGS FOR NON-TARGET SPECIES

It should not be used or should be used with caution in horses since a dose of 20 mg/kg can be fatal in these animals.

Poisoning and death may occur due to breed and herd sensitivity in goats.

It is toxic to cats and dogs and can cause death.

Used or leftover product must be disposed of according to the relevant legislation.

COMMERCIAL PRESENTATION FORM

500 g and 1 kg white polyethylene jars without a box.

PLACE AND CONDITIONS OF SALE

It is sold in pharmacies and veterinary clinics with a veterinarian's prescription. (VSP)