Kalsimin

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Product Group	:	Perfusion Solutions
Pharmaceutical Form	:	Solution for Perfusion
Active Ingredient	:	Calcium gluconate, Calcium glucoheptonate, Calcium hypophosphite, Calcium D-saccharate, Magnesium chloride hexahydrate, Boric acid
Target Animal	:	Cattle, Horse, Sheep, Goat
Package Form	:	In 100-250 ml colorless glass flacons

Composition - Pharmacological Properties
Indications – Usage
Undesirable Effects – Warnings

COMPOSITION

Kalsimin is a colorless or very light-yellow colored, clear, ready-to-use and sterile solution containing 45 g Calcium gluconate, 2 g Calcium glucoheptonate, 2 g Calcium hypophosphite, 1 g Calcium D-saccharate, 6,4 g Magnesium chloride hexahydrate and 9 g boric acid per 100 ml.

PHARMACOLOGICAL PROPERTIES

Kalsimin is a combination of calcium, magnesium prepared for parenteral administration. It is used for treatment of calcium and magnesium deficiencies and imbalances frequently encountered in all domestic animals, especially ruminants. Due to the density of the active ingredients in Kalsimin, it does not cause pain, soreness, abscess and necrosis at the application sites. Therefore, it can be safely administered by all parenteral routes.

AREA OF USE/INDICATIONS

Hypocalcemic paralysis, as a prophylactic against calcium deficiencies in all domestic animals, especially cattle, birth fever, lactation tetany, meadow and hypomagnesemic tetany, diseases known as travel and meadow tetany, rickets and osteomalacia, slowing or stopping of growth in young animals, decreased reproductive performance; allergies, poisoning, disorders of nervous origin (morbus maculosus, serum sickness, arthralgias, anaphylaxis, exanthema, hemorrhagic diathesis, hematuria, and in the sedation of allergic phenomena. ); chloroform, carbontetrachloride, organic phosphorus insecticides, especially mercury, lead, copper, tin, cadmium, and metals such as mercury, lead, copper, tin, cadmium, food poisoning and animal bites, in cases requiring high amounts of phosphorus and phosphate intake.

USAGE AND DOSAGE

Dosage Table

Calve	(200-500 kg body weight)	80-100 ml
Horse	(200-500 kg body weight)	80-100 ml
Sheep, Goat	(25-50 kg body weight)	15-25 ml

It is used intramuscularly, intravenously and subcutaneously routes.

Kalsimin Solution for Perfusion should be slowly infused for intravenous administration, and dose should be divided into 3-4 sequential doses for subcutaneous and intramuscular administrations.

SPECIAL CLINICAL INFORMATION AND SPECIAL WARNINGS FOR TARGET SPECIES

The amount of infusion to be administered should be based on the animal's body weight, clinical condition and laboratory studies. Rapid administration should be avoided. Use by heating to body temperature.

ADVERSE EFFECTS

Following intravenous calcium administration, cardiac rhythm irregularity, bradycardia, heart blockade, nausea or vomiting and reaction at the injection site may occur. However, with intramuscular and subcutaneous administration, such side effects are very rare.

DRUG INTERACTIONS

Use of calcium compounds together with oral tetracyclines will reduce absorption of tetracyclines. Moreover, calcium compounds are incompatible with neuromuscular blockers, carbonates or bicarbonates, phosphates, sulphates and tartarates. Simultaneous administration of Calcium and Vitamin D analogs may cause hypercalcemia.

SYMPTOMS OF OVERDOSE, PRECAUTIONS AND ANTIDOTE

Calcium salts are toxic for heart. In intravenous applications, heart beats should be monitored continuously. If there is an increase in the pulse rate, the application should be terminated. In case of calcium poisoning, 300 ml of 10% magnesium sulphate solution (for a normal sized cow) is administered intravenously to prevent poisoning.

WITHDRAWAL PERIODS

“0” day for meat and milk.